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Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Schalkwijk, Joost; Allman, Erik L; Jansen, Patrick A M; de Vries, Laura E; Verhoef, Julie M J; Jackowski, Suzanne; Botman, Peter N M; Beuckens-Schortinghuis, Christien A; Koolen, Karin M J; Bolscher, Judith M; Vos, Martijn W; Miller, Karen; Reeves, Stacy A; Pett, Helmi; Trevitt, Graham; Wittlin, Sergio; Scheurer, Christian; Sax, Sibylle; Fischli, Christoph; Angulo-Barturen, Iñigo; Jiménez-Diaz, Mariá Belén; Josling, Gabrielle; Kooij, Taco W A; Bonnert, Roger; Campo, Brice; Blaauw, Richard H; Rutjes, Floris P J T; Sauerwein, Robert W; Llinás, Manuel; Hermkens, Pedro H H; Dechering, Koen J.
Afiliação
  • Schalkwijk J; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands. joost.schalkwijk@radboudumc.nl k.dechering@tropiq.nl.
  • Allman EL; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA 16802 USA.
  • Jansen PAM; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  • de Vries LE; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  • Verhoef JMJ; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  • Jackowski S; St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Botman PNM; Chiralix, Nijmegen, Netherlands.
  • Beuckens-Schortinghuis CA; Chiralix, Nijmegen, Netherlands.
  • Koolen KMJ; TropIQ Health Sciences, Nijmegen, Netherlands.
  • Bolscher JM; TropIQ Health Sciences, Nijmegen, Netherlands.
  • Vos MW; TropIQ Health Sciences, Nijmegen, Netherlands.
  • Miller K; St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Reeves SA; St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Pett H; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  • Trevitt G; XenoGesis Ltd., Nottingham, UK.
  • Wittlin S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Scheurer C; University of Basel, Basel, Switzerland.
  • Sax S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Fischli C; University of Basel, Basel, Switzerland.
  • Angulo-Barturen I; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Jiménez-Diaz MB; University of Basel, Basel, Switzerland.
  • Josling G; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Kooij TWA; University of Basel, Basel, Switzerland.
  • Bonnert R; The Art of Discovery, Derio, Spain.
  • Campo B; The Art of Discovery, Derio, Spain.
  • Blaauw RH; Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA 16802 USA.
  • Rutjes FPJT; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  • Sauerwein RW; Medicines for Malaria Venture, Geneva, Switzerland.
  • Llinás M; Medicines for Malaria Venture, Geneva, Switzerland.
  • Hermkens PHH; Chiralix, Nijmegen, Netherlands.
  • Dechering KJ; Radboud University, Nijmegen, Netherlands.
Sci Transl Med ; 11(510)2019 09 18.
Article em En | MEDLINE | ID: mdl-31534021
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Pantotênico / Acetilcoenzima A / Plasmodium falciparum / Vias Biossintéticas / Antimaláricos Limite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Pantotênico / Acetilcoenzima A / Plasmodium falciparum / Vias Biossintéticas / Antimaláricos Limite: Animals / Humans / Male Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article