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Simple and robust polymer-based sensor for rapid cancer detection using serum.
Le, Ngoc D B; Singla, Arvind K; Geng, Yingying; Han, Jinsong; Seehafer, Kai; Prakash, Gyan; Moyano, Daniel F; Downey, Charlene M; Monument, Michael J; Itani, Doha; Bunz, Uwe H F; Jirik, Frank R; Rotello, Vincent M.
Afiliação
  • Le NDB; Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
  • Singla AK; Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
  • Geng Y; Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
  • Han J; Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
  • Seehafer K; Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
  • Prakash G; Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
  • Moyano DF; Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
  • Downey CM; Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
  • Monument MJ; Department of Surgery, The McCaig Institute for Bone and Joint Health, Arnie Charbonneau Cancer Institute, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
  • Itani D; Department of Pathology and Laboratory Medicine, Calgary Laboratory Services/University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
  • Bunz UHF; Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
  • Jirik FR; Department of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
  • Rotello VM; Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
Chem Commun (Camb) ; 55(76): 11458-11461, 2019 Sep 19.
Article em En | MEDLINE | ID: mdl-31535684
ABSTRACT
We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Proteínas Sanguíneas / Biomarcadores Tumorais / Corantes Fluorescentes / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Proteínas Sanguíneas / Biomarcadores Tumorais / Corantes Fluorescentes / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos