Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.

Jiang, Hui; Xue, Xiaoyu; Panda, Swarupa; Kawale, Ajinkya; Hooy, Richard M; Liang, Fengshan; Sohn, Jungsan; Sung, Patrick; Gekara, Nelson O

Jiang, Hui; Xue, Xiaoyu; Panda, Swarupa; Kawale, Ajinkya; Hooy, Richard M; Liang, Fengshan; Sohn, Jungsan; Sung, Patrick; Gekara, Nelson O.

Afiliação

Jiang H; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Xue X; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Panda S; Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, USA.
Kawale A; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Hooy RM; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Liang F; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sohn J; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Sung P; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gekara NO; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.

EMBO J ; 38(21): e102718, 2019 10 04.

Article em En | MEDLINE | ID: mdl-31544964

Assuntos

Morte Celular; Núcleo Celular/metabolismo; Cromatina/metabolismo; Instabilidade Genômica; Nucleotidiltransferases/metabolismo; Nucleotidiltransferases/fisiologia; Reparo de DNA por Recombinação; Animais; Núcleo Celular/genética; Cromatina/genética; Dano ao DNA; Células HEK293; Células HeLa; Humanos; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Nucleotidiltransferases/genética; Transdução de Sinais

Palavras-chave

cGAS; DNA repair; cancer; cell death; chromatin compaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Núcleo Celular / Morte Celular / Instabilidade Genômica / Reparo de DNA por Recombinação / Nucleotidiltransferases Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia

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