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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis, Thibaut; Negri, Joseph; Ramalingam, Nagendran; Terry-Kantor, Elizabeth; Ho, Gary P H; Fanning, Saranna; Stirtz, Georgia; Kim, Tae-Eun; Levy, Oren A; Young-Pearse, Tracy L; Selkoe, Dennis; Dettmer, Ulf.
Afiliação
  • Imberdis T; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Negri J; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Ramalingam N; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Terry-Kantor E; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Ho GPH; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Fanning S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Stirtz G; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Kim TE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Levy OA; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032.
  • Young-Pearse TL; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Selkoe D; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Dettmer U; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; udettmer@bwh.harvard.edu.
Proc Natl Acad Sci U S A ; 116(41): 20760-20769, 2019 10 08.
Article em En | MEDLINE | ID: mdl-31548371
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estearoil-CoA Dessaturase / Corpos de Inclusão / Alfa-Sinucleína / Bibliotecas de Moléculas Pequenas / Lipídeos / Mutação / Neuroblastoma Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estearoil-CoA Dessaturase / Corpos de Inclusão / Alfa-Sinucleína / Bibliotecas de Moléculas Pequenas / Lipídeos / Mutação / Neuroblastoma Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article