The significance of the placental genome and methylome in fetal and maternal health.
Hum Genet
; 139(9): 1183-1196, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31555906
ABSTRACT
The placenta is a crucial organ for supporting a healthy pregnancy, and defective development or function of the placenta is implicated in a number of complications of pregnancy that affect both maternal and fetal health, including maternal preeclampsia, fetal growth restriction, and spontaneous preterm birth. In this review, we highlight the role of the placental genome in mediating fetal and maternal health by discussing the impact of a variety of genetic alterations, from large whole-chromosome aneuploidies to single-nucleotide variants, on placental development and function. We also discuss the placental methylome in relation to its potential applications for refining diagnosis, predicting pathology, and identifying genetic variants with potential functional significance. We conclude that understanding the influence of the placental genome on common placental-mediated pathologies is critical to improving perinatal health outcomes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Complicações na Gravidez
/
Genoma Humano
/
Saúde Materna
/
Epigenoma
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Hum Genet
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá