Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.

Hotta, Masahiro; Sakatani, Takashi; Ishino, Kousuke; Wada, Ryuichi; Kudo, Mitsuhiro; Yokoyama, Yasuyuki; Yamada, Takeshi; Yoshida, Hiroshi; Naito, Zenya

Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.

Hotta, Masahiro; Sakatani, Takashi; Ishino, Kousuke; Wada, Ryuichi; Kudo, Mitsuhiro; Yokoyama, Yasuyuki; Yamada, Takeshi; Yoshida, Hiroshi; Naito, Zenya.

Afiliação

Hotta M; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, 1-1-5 Sendagi, Bunkyo-ku, Nippon Medical School, Tokyo, Japan.
Sakatani T; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan; Department of Diagnostic Pathology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan. Electronic address: takashi-sakatani@nms.ac.jp.
Ishino K; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Wada R; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Kudo M; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Yokoyama Y; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, 1-1-5 Sendagi, Bunkyo-ku, Nippon Medical School, Tokyo, Japan.
Yamada T; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, 1-1-5 Sendagi, Bunkyo-ku, Nippon Medical School, Tokyo, Japan.
Yoshida H; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, 1-1-5 Sendagi, Bunkyo-ku, Nippon Medical School, Tokyo, Japan.
Naito Z; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.

Biochem Biophys Res Commun ; 519(4): 824-831, 2019 11 19.

Article em En | MEDLINE | ID: mdl-31561852

Assuntos

Autofagia/efeitos dos fármacos; Isoxazóis/farmacologia; Receptores Citoplasmáticos e Nucleares/agonistas; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Proteína Sequestossoma-1/metabolismo; Ligante Indutor de Apoptose Relacionado a TNF/farmacologia; Autofagia/genética; Morte Celular/efeitos dos fármacos; Morte Celular/genética; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/genética; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Células HCT116; Humanos; Proteômica/métodos; Receptores Citoplasmáticos e Nucleares/genética; Receptores Citoplasmáticos e Nucleares/metabolismo; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética; Proteína Sequestossoma-1/genética; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Autophagy; Colorectal cancer; Death receptor 5; Farnesoid X receptor; Proteomics; TRAIL

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Receptores Citoplasmáticos e Nucleares / Ligante Indutor de Apoptose Relacionado a TNF / Receptores do Ligante Indutor de Apoptose Relacionado a TNF / Proteína Sequestossoma-1 / Isoxazóis Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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