Neutropenia and renal dysfunction due to intravesical cidofovir for virus-associated hemorrhagic cystitis after kidney and allogenic hematopoietic stem cell transplantations.

Shimizu, Takuya; Kondo, Tadakazu; Matsumoto, Kana; Hishizawa, Masakatsu; Yamashita, Kouhei; Takaori-Kondo, Akifumi

Shimizu, Takuya; Kondo, Tadakazu; Matsumoto, Kana; Hishizawa, Masakatsu; Yamashita, Kouhei; Takaori-Kondo, Akifumi.

Afiliação

Shimizu T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kondo T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Matsumoto K; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan.
Hishizawa M; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yamashita K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Transpl Infect Dis ; 21(6): e13185, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31571390

ABSTRACT

ABSTRACT

We present a patient with virus-associated hemorrhagic cystitis who underwent kidney and allogenic hematopoietic stem cell transplantations (allo-HSCT). Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. This might cause prolonged neutropenia and nephrotoxicity, suggesting cidofovir absorption in the blood.

Assuntos

Cidofovir/efeitos adversos; Cistite/tratamento farmacológico; Transplante de Células-Tronco Hematopoéticas/efeitos adversos; Hematúria/tratamento farmacológico; Transplante de Rim/efeitos adversos; Neutropenia/induzido quimicamente; Administração Intravesical; Aloenxertos/efeitos dos fármacos; Aloenxertos/fisiopatologia; Cidofovir/administração & dosagem; Cidofovir/farmacocinética; Cistite/complicações; Cistite/urina; Cistite/virologia; Hematúria/urina; Hematúria/virologia; Humanos; Rim/efeitos dos fármacos; Rim/fisiopatologia; Masculino; Pessoa de Meia-Idade; Distribuição Tecidual; Transplante Homólogo/efeitos adversos; Bexiga Urinária/efeitos dos fármacos; Bexiga Urinária/virologia

Palavras-chave

allogenic hematopoietic stem cell transplantation; cidofovir; intravesical; kidney transplantation; virus-associated hemorrhagic cystitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Transplante de Células-Tronco Hematopoéticas / Cistite / Cidofovir / Hematúria / Neutropenia Tipo de estudo: Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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