Predicting response to lisinopril in treating hypertension: a pilot study.
Metabolomics
; 15(10): 133, 2019 10 03.
Article
em En
| MEDLINE
| ID: mdl-31583478
ABSTRACT
INTRODUCTION:
Only ~ 50% of hypertensive patients will respond to treatment.OBJECTIVE:
This pilot study aims to identify clinical and metabolite markers that predict response to lisinopril.METHODS:
Hypertensive patients (n = 45) received lisinopril (10 mg) at their baseline visit. Blood pressures were reevaluated one week later. Responders to lisinopril (n = 19) were defined by a 10% decline in systolic blood pressure. Plasma metabolites were evaluated with mass spectrometry.RESULTS:
BMI (p = 0.009), GFR (p = 0.015) and 2-oxoglutarate were included in a logistic regression model to predict response to lisinopril.CONCLUSIONS:
Further validation cohorts are needed to confirm the predictive values of these clinical and metabolic markers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lisinopril
/
Hipertensão
/
Anti-Hipertensivos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Metabolomics
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos