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Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
Torres-Aguila, Nuria P; Carrera, Caty; Giese, Anne-Katrine; Cullell, Natalia; Muiño, Elena; Cárcel-Márquez, Jara; Gallego-Fabrega, Cristina; González-Sánchez, Jonathan; Del Mar Freijo, María; Álvarez-Sabín, José; Molina, Carlos; Ribó, Marc; Jimenez-Conde, Jordi; Roquer, Jaume; Sobrino, Tomás; Campos, Francisco; Castillo, José; Muñoz-Narbona, Lucia; Lopez-Cancio, Elena; Dàvalos, Antoni; Diaz-Navarro, Rosa; Tur, Silvia; Vives-Bauza, Cristòfol; Serrano-Heras, Gemma; Segura, Tomás; Krupinski, Jerzy; Delgado-Mederos, Raquel; Martí-Fàbregas, Joan; Heitsch, Laura; Ibañez, Laura; Cruchaga, Carlos; Rost, Natalia S; Montaner, Joan; Lee, Jin-Moo; Fernandez-Cadenas, Israel.
Afiliação
  • Torres-Aguila NP; From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
  • Carrera C; Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain (N.P.T.-A., C.C., J.M.).
  • Giese AK; Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain (N.P.T.-A., C.C., J.M.).
  • Cullell N; Neurology Department, Massachusetts General Hospital, Boston (A.-K.G., N.S.R.).
  • Muiño E; Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).
  • Cárcel-Márquez J; From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
  • Gallego-Fabrega C; From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
  • González-Sánchez J; From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
  • Del Mar Freijo M; Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).
  • Álvarez-Sabín J; From the Stroke Pharmacogenomics and Genetics Laboratory, Hospital de la Santa Creu i Sant Pau Research Institute, Barcelona Spain (N.P.T.-A., E.M., J.C.-M., C.G.-F., J.G.-S., I.F.-C.).
  • Molina C; Stroke Pharmacogenomics and Genetics Laboratory, Fundació Mútua Terrasa, Hospital Universitari Mútua Terrassa, Spain (N.C., C.G.-F., J.G.-S.).
  • Ribó M; School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom (J.G.-S., J.K.).
  • Jimenez-Conde J; Neurology Department, Hospital de Basurto, Bilbao, Spain (M.d.M.F.).
  • Roquer J; Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).
  • Sobrino T; Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).
  • Campos F; Stroke Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain (J.Á.-S., C.M., M.R.).
  • Castillo J; Neurology Department, Institut Hospital del Mar d'Investigacions Mèdiques-Hospital del Mar Barcelona, Spain (J.J.-C., J.R.).
  • Muñoz-Narbona L; Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain (J.J.-C., J.R.).
  • Lopez-Cancio E; Universitat Autónoma de Barcelona/Departamento de Ciencias Experimentales y de la Salud, Universitat Pompeu Fabra, Barcelona, Spain (J.J.-C., J.R.).
  • Dàvalos A; Neurology Department, Institut Hospital del Mar d'Investigacions Mèdiques-Hospital del Mar Barcelona, Spain (J.J.-C., J.R.).
  • Diaz-Navarro R; Neurovascular Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain (J.J.-C., J.R.).
  • Tur S; Universitat Autónoma de Barcelona/Departamento de Ciencias Experimentales y de la Salud, Universitat Pompeu Fabra, Barcelona, Spain (J.J.-C., J.R.).
  • Vives-Bauza C; Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).
  • Serrano-Heras G; Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).
  • Segura T; Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain (T.S., F.C., J.C.).
  • Krupinski J; Neurosciences Department, Hospital Germans Trias I Pujol-Universitat Autónoma de Barcelona, Barcelona, Spain (L.M.-N., A.D.).
  • Delgado-Mederos R; Stroke Unit, Hospital Universitario Central de Asturias, Oviedo, Spain (E.L.-C.).
  • Martí-Fàbregas J; Neurosciences Department, Hospital Germans Trias I Pujol-Universitat Autónoma de Barcelona, Barcelona, Spain (L.M.-N., A.D.).
  • Heitsch L; Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).
  • Ibañez L; Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).
  • Cruchaga C; Neuroscience Laboratory, Fundació Institut d'Investigació Sanitària Illes Balears, Mallorca, Spain (R.D.-N., S.T., C.V.-B.).
  • Rost NS; Neurology Department, University Hospital of Albacete, Spain (G.S.-H., T.S.).
  • Montaner J; Neurology Department, University Hospital of Albacete, Spain (G.S.-H., T.S.).
  • Lee JM; School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom (J.G.-S., J.K.).
  • Fernandez-Cadenas I; Neurology Service, Hospital Universitari Mútua Terrassa, Spain (J.K.).
Stroke ; 50(12): 3618-3621, 2019 12.
Article em En | MEDLINE | ID: mdl-31587654
ABSTRACT
Background and Purpose- Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods- Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results- Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P<5×10-8). The 14q24.3 locus was associated with acute stroke outcome (rs112809786, P=0.036) and with ACOT1 and PTGR2 gene expression. Previous polymorphisms associated with leukocyte counts in general-population did not show any significance in our study. Conclusions- We have found the first locus associated with leukocyte counts in ischemic stroke, also associated with acute outcome. Genetic analysis of acute endophenotypes could be useful to find the genetic factors associated with stroke outcome. Our findings suggested a different modulation of immune cells in stroke compared with healthy conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Acidente Vascular Cerebral / Contagem de Leucócitos / Leucócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Acidente Vascular Cerebral / Contagem de Leucócitos / Leucócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Ano de publicação: 2019 Tipo de documento: Article