miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1.
J Biochem
; 167(1): 41-48, 2020 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-31598678
ABSTRACT
The study aimed to investigate the regulatory effect of miR-146a in proliferation, invasion and migration of breast cancer and its possible mechanism via NM23-H1. The expression levels of miR-146a in breast cancer with different pathological classification were significantly increased, while the expression levels of NM23-H1 were significantly decreased, which were closely correlated. Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1. In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
MicroRNAs
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Nucleosídeo NM23 Difosfato Quinases
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Biochem
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China