CDK11 safeguards the identity of human embryonic stem cells via fine-tuning signaling pathways.

Ding, Jianyi; Fang, Zhuoqing; Liu, Xinyuan; Zhu, Zhexin; Wen, Chunsheng; Wang, Han; Gu, Junjie; Li, Qing-Run; Zeng, Rong; Li, Hui; Jin, Ying

Ding, Jianyi; Fang, Zhuoqing; Liu, Xinyuan; Zhu, Zhexin; Wen, Chunsheng; Wang, Han; Gu, Junjie; Li, Qing-Run; Zeng, Rong; Li, Hui; Jin, Ying.

Afiliação

Ding J; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Fang Z; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Liu X; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Zhu Z; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Wen C; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Wang H; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.
Gu J; Basic Clinical Research Center, Renji Hospital, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li QR; Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Zeng R; Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Li H; Basic Clinical Research Center, Renji Hospital, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jin Y; CAS Key Laboratory of Tissue Microenvironment and Tumor, Chinese Academy of Sciences, Shanghai, China.

J Cell Physiol ; 235(5): 4279-4290, 2020 05.

Article em En | MEDLINE | ID: mdl-31612516

Assuntos

Quinases Ciclina-Dependentes/metabolismo; Células-Tronco Embrionárias/fisiologia; Transdução de Sinais/fisiologia; Proliferação de Células; Quinases Ciclina-Dependentes/genética; Regulação para Baixo; Regulação da Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; MAP Quinase Quinase 4/genética; MAP Quinase Quinase 4/metabolismo; Quinases de Proteína Quinase Ativadas por Mitógeno/genética; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; Isoformas de Proteínas; Proteína Smad2/genética; Proteína Smad2/metabolismo; Proteína Smad3/genética; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta/metabolismo; Regulação para Cima; Proteínas Quinases p38 Ativadas por Mitógeno/genética; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

CDK11; MAPK signaling; TGF-ß signaling; human embryonic stem cells; protein phosphatase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Quinases Ciclina-Dependentes / Células-Tronco Embrionárias Limite: Humans Idioma: En Revista: J Cell Physiol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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