Optical Pooled Screens in Human Cells.

Feldman, David; Singh, Avtar; Schmid-Burgk, Jonathan L; Carlson, Rebecca J; Mezger, Anja; Garrity, Anthony J; Zhang, Feng; Blainey, Paul C

Feldman, David; Singh, Avtar; Schmid-Burgk, Jonathan L; Carlson, Rebecca J; Mezger, Anja; Garrity, Anthony J; Zhang, Feng; Blainey, Paul C.

Afiliação

Feldman D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Physics, MIT, Cambridge, MA 02142, USA.
Singh A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Schmid-Burgk JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Carlson RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Health Sciences and Technology, MIT, Cambridge, MA 02142, USA.
Mezger A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Garrity AJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zhang F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Cambridge, MA 02142, USA; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02142, USA; Howard Hughes Medical I
Blainey PC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA. Electronic address: pblainey@broadinstitute.org.

Cell ; 179(3): 787-799.e17, 2019 10 17.

Article em En | MEDLINE | ID: mdl-31626775

Assuntos

Testes Genéticos; Genômica; NF-kappa B/genética; Fator de Transcrição RelA/genética; Animais; Sistemas CRISPR-Cas; Linhagem Celular; Núcleo Celular/genética; Núcleo Celular/metabolismo; Humanos; Complexo Mediador/genética; RNA Guia de Cinetoplastídeos/genética

Palavras-chave

CRISPR; functional genomics; high-content screening; in situ sequencing; optical pooled screen; pooled screen

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes Genéticos / NF-kappa B / Genômica / Fator de Transcrição RelA Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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