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Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial.
Bernstein, David I; Guptill, Jeffrey; Naficy, Abdollah; Nachbagauer, Raffael; Berlanda-Scorza, Francesco; Feser, Jodi; Wilson, Patrick C; Solórzano, Alicia; Van der Wielen, Marie; Walter, Emmanuel B; Albrecht, Randy A; Buschle, Kristen N; Chen, Yao-Qing; Claeys, Carine; Dickey, Michelle; Dugan, Haley L; Ermler, Megan E; Freeman, Debra; Gao, Min; Gast, Christopher; Guthmiller, Jenna J; Hai, Rong; Henry, Carole; Lan, Linda Yu-Ling; McNeal, Monica; Palm, Anna-Karin E; Shaw, Dustin G; Stamper, Christopher T; Sun, Weina; Sutton, Victoria; Tepora, Micah E; Wahid, Rahnuma; Wenzel, Heather; Wohlbold, Teddy John; Innis, Bruce L; García-Sastre, Adolfo; Palese, Peter; Krammer, Florian.
Afiliação
  • Bernstein DI; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Guptill J; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Naficy A; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Berlanda-Scorza F; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Feser J; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Wilson PC; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Solórzano A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Van der Wielen M; GlaxoSmithKline, Wavre, Belgium.
  • Walter EB; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
  • Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Buschle KN; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Chen YQ; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Claeys C; GlaxoSmithKline, Wavre, Belgium.
  • Dickey M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Dugan HL; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Ermler ME; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; GlaxoSmithKline, Collegeville, PA, USA.
  • Freeman D; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Gao M; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Gast C; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Guthmiller JJ; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Hai R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Microbiology and Plant Pathology, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
  • Henry C; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Lan LY; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • McNeal M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Palm AE; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Shaw DG; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Stamper CT; The Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Sun W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sutton V; Duke Early Phase Clinical Research Unit, Duke Clinical Research Institute, Durham, NC, USA.
  • Tepora ME; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Wahid R; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Wenzel H; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • Wohlbold TJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Innis BL; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA.
  • García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: florian.krammer@mssm.edu.
Lancet Infect Dis ; 20(1): 80-91, 2020 01.
Article em En | MEDLINE | ID: mdl-31630990
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Adjuvantes Imunológicos / Vacinação / Influenza Humana / Hemaglutininas Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Lancet Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Adjuvantes Imunológicos / Vacinação / Influenza Humana / Hemaglutininas Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Lancet Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos