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An open-label, single-arm pilot study of EUS-guided brachytherapy with phosphorus-32 microparticles in combination with gemcitabine +/- nab-paclitaxel in unresectable locally advanced pancreatic cancer (OncoPaC-1): Technical details and study protocol.
Bhutani, Manoop S; Klapman, Jason B; Tuli, Richard; El-Haddad, Ghassan; Hoffe, Sarah; Wong, Franklin C L; Chasen, Beth; Fogelman, David R; Lo, Simon K; Nissen, Nicholas N; Hendifar, Andrew E; Varadhachary, Gauri; Katz, Matthew H G; Erwin, William D; Koay, Eugene J; Tamm, Eric P; Singh, Ben S; Mehta, Rutika; Wolff, Robert A; Soman, Ashish; Cazacu, Irina M; Herman, Joseph M.
Afiliação
  • Bhutani MS; Department of Gastroenterology, Hepatology and Nutrition, Houston, TX, USA.
  • Klapman JB; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
  • Tuli R; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • El-Haddad G; Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, FL, USA.
  • Hoffe S; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA.
  • Wong FCL; Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chasen B; Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Fogelman DR; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lo SK; Division of Digestive and Liver Diseases, Cedars Sinai Medical Center, Los Angeles, CA, USA.
  • Nissen NN; Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA.
  • Hendifar AE; Department of Hematology/Oncology, Cedars Sinai Medical Center, Los Angeles, CA, USA.
  • Varadhachary G; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Katz MHG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Erwin WD; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Koay EJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Tamm EP; Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Singh BS; Department of Gastroenterology, Hepatology and Nutrition, Houston, TX, USA.
  • Mehta R; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
  • Wolff RA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Soman A; Department of OncoSil Medical Ltd., Sydney, Australia.
  • Cazacu IM; Department of Gastroenterology, Hepatology and Nutrition, Houston, TX, USA.
  • Herman JM; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Endosc Ultrasound ; 9(1): 24-30, 2020.
Article em En | MEDLINE | ID: mdl-31670288
ABSTRACT
Current treatment options for patients with unresectable locally advanced pancreatic cancer (LAPC) include chemotherapy alone or followed by chemoradiation or stereotactic body radiotherapy. However, the prognosis for these patients remains poor, with a median overall survival <12 months. Therefore, novel treatment options are needed. Currently, there is no brachytherapy device approved for pancreatic cancer treatment. Hereby, we present the protocol of a prospective, multicenter, interventional, open-label, single-arm pilot study (OncoPac-1, Clinicaltrial.gov-NCT03076216) aiming to determine the safety and efficacy of Phosphorus-32 when implanted directly into pancreatic tumors using EUS guidance, for patients with unresectable LAPC undergoing chemotherapy (gemcitabine ± nab-paclitaxel).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Idioma: En Revista: Endosc Ultrasound Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Idioma: En Revista: Endosc Ultrasound Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos