Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses.

Kordalivand, Neda; Tondini, Elena; Lau, Chun Yin Jerry; Vermonden, Tina; Mastrobattista, Enrico; Hennink, Wim E; Ossendorp, Ferry; Nostrum, Cornelus F van

Kordalivand, Neda; Tondini, Elena; Lau, Chun Yin Jerry; Vermonden, Tina; Mastrobattista, Enrico; Hennink, Wim E; Ossendorp, Ferry; Nostrum, Cornelus F van.

Afiliação

Kordalivand N; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Tondini E; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Lau CYJ; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Vermonden T; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Mastrobattista E; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Hennink WE; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands. Electronic address: W.E.Hennink@uu.nl.
Ossendorp F; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Nostrum CFV; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

J Control Release ; 315: 114-125, 2019 12 10.

Article em En | MEDLINE | ID: mdl-31672626

Assuntos

Vacinas Anticâncer/administração & dosagem; Imunoterapia/métodos; Nanogéis; Peptídeos/administração & dosagem; Adjuvantes Imunológicos/administração & dosagem; Animais; Antígenos/imunologia; Linfócitos T CD8-Positivos/imunologia; Vacinas Anticâncer/imunologia; Cátions; Células Dendríticas/imunologia; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Ovalbumina/imunologia; Tamanho da Partícula; Peptídeos/imunologia; Poli I-C/imunologia

Palavras-chave

Cancer immunotherapy; Cationic nanogels; Synthetic long peptides; T-cell responses

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Vacinas Anticâncer / Nanogéis / Imunoterapia Limite: Animals Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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