Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules.

Crowell, Susan R; Wang, Kathryn; Famili, Amin; Shatz, Whitney; Loyet, Kelly M; Chang, Vincent; Liu, Yanqiu; Prabhu, Saileta; Kamath, Amrita V; Kelley, Robert F

Crowell, Susan R; Wang, Kathryn; Famili, Amin; Shatz, Whitney; Loyet, Kelly M; Chang, Vincent; Liu, Yanqiu; Prabhu, Saileta; Kamath, Amrita V; Kelley, Robert F.

Afiliação

Crowell SR; Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, CA, USA.
Wang K; Drug Delivery, Genentech, South San Francisco, CA, USA.
Famili A; Drug Delivery, Genentech, South San Francisco, CA, USA.
Shatz W; Protein Chemistry, Genentech, South San Francisco, CA, USA.
Loyet KM; Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
Chang V; Bioanalytical Sciences, Genentech, South San Francisco, CA, USA.
Liu Y; Bioanalytical Sciences, Genentech, South San Francisco, CA, USA.
Prabhu S; Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, CA, USA.
Kamath AV; Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, CA, USA.
Kelley RF; Drug Delivery, Genentech, South San Francisco, CA, USA.

Transl Vis Sci Technol ; 8(6): 1, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31695962

Palavras-chave

charge; hydrodynamic radius; hydrophobicity; ocular pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Vis Sci Technol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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