The effects of calcitonin on idiopathic nephrolithiasis. Evidence of bone involvement in fasting hypercalciuria.
J Endocrinol Invest
; 11(7): 509-13, 1988.
Article
em En
| MEDLINE
| ID: mdl-3171110
ABSTRACT
This study was performed to evaluate the antihypercalciuric effect of calcitonin (CT), a potent inhibitor of bone osteoclastic activity, on idiopathic hypercalciuria (IH). Forty-two stone formers were studied 18 suffered from fasting hypercalciuria (FH), 12 from nonfasting hypercalciuria (NFH) and 12 were normocalciuric stone formers (NSF). All patients received CT, 25 U/day sc for a period of 15 days. CT caused a statistically significant drop in urine calcium, phosphorus and hydroxyproline (OH-proline) excretion in FH patients and a concomitant increase in serum PTH levels. In this group the percentage variation (D%) of urine calcium decrease was linearly correlated with D% decrease in urine OH-proline. These results support the hypothesis that pathological bone reabsorption might be involved in the genesis of FH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcitonina
/
Cálculos Renais
/
Cálcio
Limite:
Humans
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Itália