Suppression of Human Platelet Activation via Integrin &#945;<sub>IIb</sub>ß<sub>3</sub> Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene.

Hsia, Chih-Wei; Tsai, Cheng-Lin; Sheu, Joen-Rong; Lu, Wan-Jung; Hsia, Chih-Hsuan; Velusamy, Marappan; Jayakumar, Thanasekaran; Li, Jiun-Yi

Suppression of Human Platelet Activation via Integrin α_IIbß₃ Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene.

Hsia, Chih-Wei; Tsai, Cheng-Lin; Sheu, Joen-Rong; Lu, Wan-Jung; Hsia, Chih-Hsuan; Velusamy, Marappan; Jayakumar, Thanasekaran; Li, Jiun-Yi.

Afiliação

Hsia CW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Tsai CL; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan.
Sheu JR; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Lu WJ; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsia CH; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan.
Velusamy M; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Jayakumar T; Department of Medical Research, Taipei Medical University Hospital, Taipei 110, Taiwan.
Li JY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Int J Mol Sci ; 20(22)2019 Nov 08.

Article em En | MEDLINE | ID: mdl-31717348

Assuntos

Cumarínicos/uso terapêutico; Ativação Plaquetária/efeitos dos fármacos; Complexo Glicoproteico GPIIb-IIIa de Plaquetas/metabolismo; Embolia Pulmonar/tratamento farmacológico; Embolia Pulmonar/mortalidade; Transdução de Sinais; Trifosfato de Adenosina/metabolismo; Animais; Plaquetas/efeitos dos fármacos; Cálcio/metabolismo; Cumarínicos/química; Cumarínicos/farmacologia; Humanos; Camundongos; Nucleotídeos Cíclicos/metabolismo; Selectina-P/metabolismo; Fosforilação/efeitos dos fármacos; Embolia Pulmonar/sangue; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

ERK1/2/JNK1/2; arterial thrombosis; auraptene; experimental mice; human platelet

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Embolia Pulmonar / Transdução de Sinais / Ativação Plaquetária / Complexo Glicoproteico GPIIb-IIIa de Plaquetas / Cumarínicos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan

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