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Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.
Yildirim, Ferah; Ng, Christopher W; Kappes, Vincent; Ehrenberger, Tobias; Rigby, Siobhan K; Stivanello, Victoria; Gipson, Theresa A; Soltis, Anthony R; Vanhoutte, Peter; Caboche, Jocelyne; Housman, David E; Fraenkel, Ernest.
Afiliação
  • Yildirim F; Department of Neuropsychiatry, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany; ferah.yildirim@charite.de dhousman@mit.edu fraenkel@mit.edu.
  • Ng CW; NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Kappes V; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Ehrenberger T; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Rigby SK; Neuroscience Paris Seine-Institut de Biologie Paris-Seine, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, 75005 Paris, France.
  • Stivanello V; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Gipson TA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Soltis AR; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Vanhoutte P; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Caboche J; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Housman DE; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Fraenkel E; Neuroscience Paris Seine-Institut de Biologie Paris-Seine, INSERM UMRS 1130/CNRS UMR8246, Sorbonne University, Université Pierre et Marie Curie, 75005 Paris, France.
Proc Natl Acad Sci U S A ; 116(49): 24840-24851, 2019 12 03.
Article em En | MEDLINE | ID: mdl-31744868
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Proteínas Elk-1 do Domínio ets / Epigenômica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Proteínas Elk-1 do Domínio ets / Epigenômica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article