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Piltunines A-F from the Marine-Derived Fungus Penicillium piltunense KMM 4668.
Afiyatullov, Shamil Sh; Zhuravleva, Olesya I; Antonov, Alexandr S; Leshchenko, Elena V; Pivkin, Mikhail V; Khudyakova, Yuliya V; Denisenko, Vladimir A; Pislyagin, Evgeny A; Kim, Natalya Yu; Berdyshev, Dmitrii V; Amsberg, Gunhild von; Dyshlovoy, Sergey A.
Afiliação
  • Afiyatullov SS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Zhuravleva OI; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Antonov AS; School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia.
  • Leshchenko EV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Pivkin MV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Khudyakova YV; School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia.
  • Denisenko VA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Pislyagin EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Kim NY; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Berdyshev DV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Amsberg GV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
  • Dyshlovoy SA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
Mar Drugs ; 17(11)2019 Nov 18.
Article em En | MEDLINE | ID: mdl-31752168
ABSTRACT
Six new carotane sesquiterpenoids piltunines A-F (1-6) together with known compounds (7-9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1-7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Sesquiterpenos / Macrófagos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Sesquiterpenos / Macrófagos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Federação Russa