Detection of rare reciprocal RUNX1 rearrangements by next-generation sequencing in acute myeloid leukemia.

Flach, Johanna; Shumilov, Evgenii; Joncourt, Raphael; Porret, Naomi; Tchinda, Joëlle; Legros, Myriam; Scarpelli, Ilaria; Hewer, Ekkehard; Novak, Urban; Schoumans, Jacqueline; Bacher, Ulrike; Pabst, Thomas

Flach, Johanna; Shumilov, Evgenii; Joncourt, Raphael; Porret, Naomi; Tchinda, Joëlle; Legros, Myriam; Scarpelli, Ilaria; Hewer, Ekkehard; Novak, Urban; Schoumans, Jacqueline; Bacher, Ulrike; Pabst, Thomas.

Afiliação

Flach J; Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany.
Shumilov E; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany.
Joncourt R; University Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland.
Porret N; University Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland.
Tchinda J; Oncology Laboratory, University Children's Hospital Zurich, Zurich, Switzerland.
Legros M; Center of Laboratory Medicine (ZLM), Inselspital, Bern University Hospital, Bern, Switzerland.
Scarpelli I; Department of Cancer Genetics, Laboratory Department, CHUV, University of Lausanne, Lausanne, Switzerland.
Hewer E; Institute of Pathology, University of Bern, Bern, Switzerland.
Novak U; Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
Schoumans J; Department of Cancer Genetics, Laboratory Department, CHUV, University of Lausanne, Lausanne, Switzerland.
Bacher U; University Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland.
Pabst T; Center of Laboratory Medicine (ZLM), Inselspital, Bern University Hospital, Bern, Switzerland.

Genes Chromosomes Cancer ; 59(4): 268-274, 2020 04.

Article em En | MEDLINE | ID: mdl-31756777

Assuntos

Subunidade alfa 2 de Fator de Ligação ao Core/genética; Rearranjo Gênico; Leucemia Mieloide Aguda/diagnóstico; Leucemia Mieloide Aguda/genética; Translocação Genética; Idoso; Biomarcadores Tumorais; Linhagem Celular Tumoral; Cromossomos Humanos Par 16; Cromossomos Humanos Par 21; Estudos de Associação Genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Hibridização in Situ Fluorescente; Masculino; Proteínas de Fusão Oncogênica/genética; Proteínas Repressoras/genética

Palavras-chave

acute myeloid leukemia; myeloid gene panel; new minimal residual disease marker; next-generation sequencing; rare RUNX1 rearrangements

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Rearranjo Gênico / Leucemia Mieloide Aguda / Subunidade alfa 2 de Fator de Ligação ao Core Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: Genes Chromosomes Cancer Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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