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Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18F-Labeled Positron Emission Tomography Probes via I-SPANC.
Ghiassian, Sara; Yu, Lihai; Gobbo, Pierangelo; Nazemi, Ali; Romagnoli, Tommaso; Luo, Wilson; Luyt, Leonard G; Workentin, Mark S.
Afiliação
  • Ghiassian S; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Yu L; London Regional Cancer Program, 800 Commissioners Rd. E., London N6A 5W9, Ontario, Canada.
  • Gobbo P; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Nazemi A; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Romagnoli T; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Luo W; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Luyt LG; Department of Chemistry and the Center for Materials and Biomaterials Research and Department of Oncology, The University of Western Ontario, London N6A 5B7, Ontario, Canada.
  • Workentin MS; London Regional Cancer Program, 800 Commissioners Rd. E., London N6A 5W9, Ontario, Canada.
ACS Omega ; 4(21): 19106-19115, 2019 Nov 19.
Article em En | MEDLINE | ID: mdl-31763533
ABSTRACT
A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition reactions has been synthesized. These nitrone-AuNPs were characterized in detail using 1H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone-AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá