Efficiency of Penetration of Dopamine and Serotonin Peptide Derivatives through the Artificial Membranes.
Dokl Biochem Biophys
; 488(1): 354-356, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31768859
ABSTRACT
A mass spectrometric method has been developed for determining the content of dopamine and serotonin derivatives, which allows evaluating the efficiency of their penetration through artificial membranes depending on the structure of their peptide fragment. In this case, the diffusion of dopamine and serotonin derivatives through the membrane occurred as a result of competitive interactions. It was shown which compounds in this mixture more easily penetrate through artificial membranes. It was found that the most promising in terms of overcoming the BBB are Boc-Pro-Srt and Boc-Pro-DOPA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Dopamina
/
Serotonina
/
Membranas Artificiais
Limite:
Humans
Idioma:
En
Revista:
Dokl Biochem Biophys
Assunto da revista:
BIOFISICA
/
BIOQUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Federação Russa