Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats.
Bull Exp Biol Med
; 168(2): 250-253, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31776957
ABSTRACT
We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Prolina
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Inibidores da Agregação Plaquetária
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Hormônio Adrenocorticotrópico
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Fibrinólise
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Hemostasia
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Anticoagulantes
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Federação Russa