Modeling the Evolution of Human Brain Development Using Organoids.

Muchnik, Sydney Keaton; Lorente-Galdos, Belen; Santpere, Gabriel; Sestan, Nenad

Muchnik, Sydney Keaton; Lorente-Galdos, Belen; Santpere, Gabriel; Sestan, Nenad.

Afiliação

Muchnik SK; Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Lorente-Galdos B; Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Santpere G; Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA; Neurogenomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Medical Research Institute, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barc
Sestan N; Departments of Genetics, Psychiatry, and Comparative Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale Child Study Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: nenad.sestan@yale.edu.

Cell ; 179(6): 1250-1253, 2019 11 27.

Article em En | MEDLINE | ID: mdl-31778651

RESUMO

In a recent issue of Nature, Kanton et al. explore human brain evolution and development by profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chimpanzee, and macaque stem cells. Their results reveal key molecular characteristics that differentiate humans and non-human primates at the earliest stages of brain development.

Assuntos

Genômica; Organoides; Animais; Encéfalo; Humanos; Pan troglodytes; Transcriptoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / Genômica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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