No association between anti-thyroidperoxidase antibodies and bipolar disorder: a study in the Dutch Bipolar Cohort and a meta-analysis.
Psychoneuroendocrinology
; 112: 104518, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31780186
ABSTRACT
BACKGROUND:
Thyroid autoimmunity has been associated with bipolar disorder (BD). However, results from previous studies on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent.OBJECTIVES:
The aim of the present study is to investigate whether the seroprevalence and titer levels of TPO-abs are related to BD.METHOD:
TPO-abs were measured in plasma samples of 760 patients with bipolar disorder, 261 first-degree relatives and 363 controls by enzyme-linked immunosorbent assay (ELISA). To address methodological limitations of previous studies, we assessed clinical characteristics with several (self-reported) questionnaires to investigate whether TPO-abs positivity is related to particular clinical subgroups of BD patients. We performed an additional meta-analysis of seroprevalences of TPO-abs in BD patients including data from present and previous studies.RESULTS:
Seroprevalence or titer levels of TPO-abs did not significantly differ between patients with BD, their first-degree relatives, and controls. In BD patients, the prevalence of TPO-abs was unrelated to specific clinical factors, including lithium use. Our meta-analysis of twelve studies showed an overall odds ratio of 1.3 (CI 95 % 0.7-2.3; pâ¯=â¯0.30), reaffirming the absence of an association of BD with TPO-abs.CONCLUSIONS:
In the largest study of TPO-abs in BD to date, our findings indicate that TPO-abs are not associated with (the risk for) bipolar disorder.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Autoantígenos
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Doenças Autoimunes
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Transtorno Bipolar
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Proteínas de Ligação ao Ferro
/
Iodeto Peroxidase
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
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Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Psychoneuroendocrinology
Ano de publicação:
2020
Tipo de documento:
Article