Fly model sheds light on brain disease.

Berryer, Martin H; Kosmaczewski, Sara G; Barrett, Lindy E

Berryer, Martin H; Kosmaczewski, Sara G; Barrett, Lindy E.

Afiliação

Berryer MH; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.
Kosmaczewski SG; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States.
Barrett LE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.

Elife ; 82019 12 06.

Article em En | MEDLINE | ID: mdl-31808420

ABSTRACT

ABSTRACT

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPÉ contributes to the progressive brain disease CLN4.

Assuntos

Encefalopatias; Dípteros; Lipofuscinoses Ceroides Neuronais; Animais; Humanos

Palavras-chave

D. melanogaster; cysteine-string protein; lysosome; neurodegeneration; neuronal ceroid lipofuscinosis; neuroscience

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatias / Dípteros / Lipofuscinoses Ceroides Neuronais Limite: Animals / Humans Idioma: En Revista: Elife Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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