Lineariifolianoids M-O, three rare sesquiterpene lactone dimers inhibiting NO production from Inula lineariifolia.
Fitoterapia
; 141: 104454, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31857181
ABSTRACT
Three rare squiterpene lactone dimers lineariifolianoids M-O (1-3) were isolated from Inula lineariifolia for the first time. Their structures and absolute configuration were established on the basis of by NMR and MS spectroscopic data and X-ray crystallography. Furthermore, those three compounds exhibited significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 1.421, 1.087 and 1.243 µM, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Inula
/
Lactonas
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2020
Tipo de documento:
Article