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Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity.
Chen, Xin; Chen, Xinyang; Steimbach, Raphael R; Wu, Tong; Li, Hongmei; Dan, Wenjia; Shi, Peidong; Cao, Chenyu; Li, Ding; Miller, Aubry K; Qiu, Zhixia; Gao, Jinming; Zhu, Yong.
Afiliação
  • Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Steimbach RR; Cancer Drug Development Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany; Biosciences Faculty, University of Heidelberg, 69120, Heidelberg, Germany.
  • Wu T; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Li H; School of Science, China Pharmaceutical University, Nanjing, 210009, PR China.
  • Dan W; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Shi P; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Cao C; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Li D; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China.
  • Miller AK; Cancer Drug Development Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
  • Qiu Z; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
  • Gao J; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, PR China. Electronic address: jinminggao@nwsuaf.edu.cn.
  • Zhu Y; School of Science, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: zhuyong@cpu.edu.cn.
Eur J Med Chem ; 187: 111950, 2020 Feb 01.
Article em En | MEDLINE | ID: mdl-31865013
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Histona Desacetilases / Desacetilase 6 de Histona / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Histona Desacetilases / Desacetilase 6 de Histona / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article