Recent advances in the discovery and development of glyoxalase I inhibitors.

Jin, Tian; Zhao, Lu; Wang, Hong-Ping; Huang, Mao-Lin; Yue, Yan; Lu, Chichong; Zheng, Zhe-Bin

Jin, Tian; Zhao, Lu; Wang, Hong-Ping; Huang, Mao-Lin; Yue, Yan; Lu, Chichong; Zheng, Zhe-Bin.

Afiliação

Jin T; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, People's Republic of China. Electronic address: jintian@cdu.edu.cn.
Zhao L; Sichuan Institute for Food and Drug Control, Chengdu 611731, People's Republic of China. Electronic address: zhaolu0309@126.com.
Wang HP; Sichuan Institute for Food and Drug Control, Chengdu 611731, People's Republic of China.
Huang ML; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, People's Republic of China.
Yue Y; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, People's Republic of China.
Lu C; Department of Chemistry, School of Science, Beijing Technology and Business University, Beijing 100048, People's Republic of China. Electronic address: luchichong@btbu.edu.cn.
Zheng ZB; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, People's Republic of China. Electronic address: zhebinzheng@hotmail.com.

Bioorg Med Chem ; 28(4): 115243, 2020 02 15.

Article em En | MEDLINE | ID: mdl-31879183

Assuntos

Produtos Biológicos/farmacologia; Desenvolvimento de Medicamentos; Inibidores Enzimáticos/farmacologia; Lactoilglutationa Liase/antagonistas & inibidores; Produtos Biológicos/síntese química; Produtos Biológicos/química; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Humanos; Lactoilglutationa Liase/metabolismo; Estrutura Molecular

Palavras-chave

Fragment-based drug discovery strategy; GSH-based inhibitors; High throughput screening; Natural or natural product-based inhibitors; Non-GSH-based inhibitors; Photo-affinity labeling and affinity pull-down protocols

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Inibidores Enzimáticos / Desenvolvimento de Medicamentos / Lactoilglutationa Liase Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article

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