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X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
Thomaston, Jessica L; Konstantinidi, Athina; Liu, Lijun; Lambrinidis, George; Tan, Jingquan; Caffrey, Martin; Wang, Jun; Degrado, William F; Kolocouris, Antonios.
Afiliação
  • Thomaston JL; Department of Pharmaceutical Chemistry , University of California San Francisco , San Francisco , California 94158 , United States.
  • Konstantinidi A; Membrane Structural and Functional Biology (MS&FB) Group, School of Medicine and School of Biochemistry and Immunology , Trinity College Dublin , Dublin D02 R590 , Ireland.
  • Liu L; Department of Pharmaceutical Chemistry , National and Kapodistrian University of Athens , 15771 Athens , Greece.
  • Lambrinidis G; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Shenzhen 518055 , China.
  • Tan J; DLX Scientific , Lawrence , Kansas 66049 , United States.
  • Caffrey M; Department of Pharmaceutical Chemistry , National and Kapodistrian University of Athens , 15771 Athens , Greece.
  • Wang J; Membrane Structural and Functional Biology (MS&FB) Group, School of Medicine and School of Biochemistry and Immunology , Trinity College Dublin , Dublin D02 R590 , Ireland.
  • Degrado WF; Membrane Structural and Functional Biology (MS&FB) Group, School of Medicine and School of Biochemistry and Immunology , Trinity College Dublin , Dublin D02 R590 , Ireland.
  • Kolocouris A; Department of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , Tucson , Arizona 85721 , United States.
Biochemistry ; 59(4): 627-634, 2020 02 04.
Article em En | MEDLINE | ID: mdl-31894969
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adamantano / Proteínas da Matriz Viral Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Biochemistry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adamantano / Proteínas da Matriz Viral Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Biochemistry Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos