JAK3 inhibitors based on thieno[3,2-d]pyrimidine scaffold: design, synthesis and bioactivity evaluation for the treatment of B-cell lymphoma.

Chi, Fuyun; Chen, Lixue; Wang, Changyuan; Li, Lei; Sun, Xiuli; Xu, Youjun; Ma, Tengyue; Liu, Kexin; Ma, Xiaodong; Shu, Xiaohong

Chi, Fuyun; Chen, Lixue; Wang, Changyuan; Li, Lei; Sun, Xiuli; Xu, Youjun; Ma, Tengyue; Liu, Kexin; Ma, Xiaodong; Shu, Xiaohong.

Afiliação

Chi F; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China.
Chen L; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China; School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Wang C; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China.
Li L; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China.
Sun X; Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China.
Xu Y; School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Ma T; Dalian Buyun Biotechnology Co., Ltd. 116085, PR China.
Liu K; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China.
Ma X; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. Electronic address: xiaodong.ma@139.com.
Shu X; College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. Electronic address: xiaohong_shu@dlmedu.edu.cn.

Bioorg Chem ; 95: 103542, 2020 01.

Article em En | MEDLINE | ID: mdl-31918398

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Janus Quinase 3/antagonistas & inibidores; Linfoma de Células B/tratamento farmacológico; Inibidores de Proteínas Quinases/farmacologia; Pirimidinas/química; Tirosina Quinase da Agamaglobulinemia/antagonistas & inibidores; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Humanos; Linfoma de Células B/patologia; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/uso terapêutico; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

B-cell lymphoma; JAK3 inhibitor; Thieno[3,2-d]pyrimidines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Desenho de Fármacos / Linfoma de Células B / Inibidores de Proteínas Quinases / Janus Quinase 3 / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

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