Combining molecular dynamics simulations and experimental analyses in protein misfolding.

Wille, Holger; Dorosh, Lyudmyla; Amidian, Sara; Schmitt-Ulms, Gerold; Stepanova, Maria

Wille, Holger; Dorosh, Lyudmyla; Amidian, Sara; Schmitt-Ulms, Gerold; Stepanova, Maria.

Afiliação

Wille H; Department of Biochemistry, University of Alberta, Edmonton, Canada; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
Dorosh L; Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.
Amidian S; Department of Biochemistry, University of Alberta, Edmonton, Canada; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Schmitt-Ulms G; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Stepanova M; Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada.

Adv Protein Chem Struct Biol ; 118: 33-110, 2019.

Article em En | MEDLINE | ID: mdl-31928730

Assuntos

Peptídeos beta-Amiloides/metabolismo; Amiloide/metabolismo; Simulação de Dinâmica Molecular; Dobramento de Proteína; Peptídeos beta-Amiloides/genética; Humanos; Mutação; Doenças Neurodegenerativas/metabolismo; Conformação Proteica

Palavras-chave

Amyloid fibril; Neurodegenerative disease; Oligomer; Prion; Protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Dobramento de Proteína / Simulação de Dinâmica Molecular / Amiloide Limite: Humans Idioma: En Revista: Adv Protein Chem Struct Biol Assunto da revista: BIOLOGIA / BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá

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