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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cheng, Wenwen; Gonzalez, Ian; Pan, Warren; Tsang, Anthony H; Adams, Jessica; Ndoka, Ermelinda; Gordian, Desiree; Khoury, Basma; Roelofs, Karen; Evers, Simon S; MacKinnon, Andrew; Wu, Shuangcheng; Frikke-Schmidt, Henriette; Flak, Jonathan N; Trevaskis, James L; Rhodes, Christopher J; Fukada, So-Ichiro; Seeley, Randy J; Sandoval, Darleen A; Olson, David P; Blouet, Clemence; Myers, Martin G.
Afiliação
  • Cheng W; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Gonzalez I; Division of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
  • Pan W; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA.
  • Tsang AH; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Adams J; Division of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA.
  • Ndoka E; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Gordian D; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Khoury B; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • Roelofs K; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • Evers SS; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • MacKinnon A; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Wu S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
  • Frikke-Schmidt H; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • Flak JN; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Trevaskis JL; Cardiovascular, Renal and Metabolic Diseases, AstraZenica LLC, Gaithersburg, MD 20878, USA.
  • Rhodes CJ; Cardiovascular, Renal and Metabolic Diseases, AstraZenica LLC, Gaithersburg, MD 20878, USA.
  • Fukada SI; Laboratory of Molecular and Cellular Physiology, Osaka University, Osaka 565-0871, Japan.
  • Seeley RJ; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • Sandoval DA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
  • Olson DP; Division of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
  • Blouet C; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: csb69@medschl.cam.ac.uk.
  • Myers MG; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Division of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, M
Cell Metab ; 31(2): 301-312.e5, 2020 02 04.
Article em En | MEDLINE | ID: mdl-31955990
ABSTRACT
To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decreased food intake and body weight but (unlike neighboring CckNTS cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a non-aversive suppression of food intake. While both CalcrNTS and CckNTS neurons decreased feeding via projections to the PBN, CckNTS cells activated aversive CGRPPBN cells while CalcrNTS cells activated distinct non-CGRP PBN cells. Hence, CalcrNTS cells suppress feeding via non-aversive, non-CGRP PBN targets. Additionally, silencing CalcrNTS cells blunted food intake suppression by gut peptides and nutrients, increasing food intake and promoting obesity. Hence, CalcrNTS neurons define a hindbrain system that participates in physiological energy balance and suppresses food intake without activating aversive systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Solitário / Receptores da Calcitonina / Ingestão de Alimentos / Metabolismo Energético / Neurônios Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Solitário / Receptores da Calcitonina / Ingestão de Alimentos / Metabolismo Energético / Neurônios Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos