Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D<sub>2</sub> Derivatives Modified at the Side Chain and the A-Ring.

Milczarek, Magdalena; Chodynski, Michal; Pietraszek, Anita; Stachowicz-Suhs, Martyna; Yasuda, Kaori; Sakaki, Toshiyuki; Wietrzyk, Joanna; Kutner, Andrzej

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D₂ Derivatives Modified at the Side Chain and the A-Ring.

Milczarek, Magdalena; Chodynski, Michal; Pietraszek, Anita; Stachowicz-Suhs, Martyna; Yasuda, Kaori; Sakaki, Toshiyuki; Wietrzyk, Joanna; Kutner, Andrzej.

Afiliação

Milczarek M; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.
Chodynski M; Department of Chemistry, Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Pietraszek A; Department of Chemistry, Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Stachowicz-Suhs M; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.
Yasuda K; Department of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Sakaki T; Department of Pharmaceutical Engineering, Toyama Prefectural University, Toyama 939-0398, Japan.
Wietrzyk J; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla, 53-114 Wroclaw, Poland.
Kutner A; Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.

Int J Mol Sci ; 21(2)2020 Jan 18.

Article em En | MEDLINE | ID: mdl-31963716

Assuntos

Antineoplásicos/síntese química; Neoplasias Colorretais/metabolismo; Ergocalciferóis/síntese química; Vitamina D3 24-Hidroxilase/metabolismo; Vitamina D/análogos & derivados; Antineoplásicos/química; Antineoplásicos/farmacologia; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Sinergismo Farmacológico; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Ergocalciferóis/química; Ergocalciferóis/farmacologia; Fluoruracila/farmacologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Células HCT116; Células HT29; Humanos; Estrutura Molecular; Transdução de Sinais/efeitos dos fármacos; Vitamina D/química

Palavras-chave

1,25-dihydroxyergocalciferol analogs; CYP24A1-dependent metabolism; antiproliferative activity in vitro; double-point modified vitamin D2 analogs; human colorectal cancer cell lines; vitamin D derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Neoplasias Colorretais / Ergocalciferóis / Vitamina D3 24-Hidroxilase / Antineoplásicos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

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