Open-Air Stereoselective Construction of C-Aryl Glycosides.
Org Lett
; 22(3): 1144-1148, 2020 02 07.
Article
em En
| MEDLINE
| ID: mdl-31971808
ABSTRACT
A new methodology of stereoselective C-glycosylation has been developed with 3,4-O-carbonate glycals and boronic acids, catalyzed by 1,2-bis(phenylsulfinyl)ethane palladium(II) acetate under open-air conditions at room temperature. This mild method is simple in operation, wide in substrate range, and tolerant in alcoholic/phenolic hydroxyl and amino groups. High to excellent yields were observed for all substrates tested, with the driving force mainly contributed by decarboxylation. Meanwhile, the high 1,4-trans-selectivity was achieved by steric effects as proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicosídeos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article