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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
Rab, Minke A E; Van Oirschot, Brigitte A; Kosinski, Penelope A; Hixon, Jeffrey; Johnson, Kendall; Chubukov, Victor; Dang, Lenny; Pasterkamp, Gerard; Van Straaten, Stephanie; Van Solinge, Wouter W; Van Beers, Eduard J; Kung, Charles; Van Wijk, Richard.
Afiliação
  • Rab MAE; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht.
  • Van Oirschot BA; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands.
  • Kosinski PA; Agios Pharmaceuticals, Inc., Cambridge, MA.
  • Hixon J; KSQ Therapeutics, Cambridge, MA.
  • Johnson K; Agios Pharmaceuticals, Inc., Cambridge, MA.
  • Chubukov V; Agios Pharmaceuticals, Inc., Cambridge, MA.
  • Dang L; Agios Pharmaceuticals, Inc., Cambridge, MA.
  • Pasterkamp G; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands.
  • Van Straaten S; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht.
  • Van Solinge WW; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht.
  • Van Beers EJ; Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Kung C; Agios Pharmaceuticals, Inc., Cambridge, MA.
  • Van Wijk R; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht.
Haematologica ; 106(1): 238-249, 2021 01 01.
Article em En | MEDLINE | ID: mdl-31974203
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Eritrócitos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Eritrócitos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2021 Tipo de documento: Article