Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids.

Ferrone, S; Whiteside, T L

Ferrone, S; Whiteside, T L.

Afiliação

Ferrone S; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA. sferrone@mgh.harvard.edu.
Whiteside TL; Departments of Pathology, Immunology and Otolaryngology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, 15213, Pittsburgh, PA, USA.

HNO ; 68(2): 100-105, 2020 Feb.

Article em En | MEDLINE | ID: mdl-32006045

RESUMO

This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4), which is used as a marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host's immune system.

Assuntos

Proteoglicanas de Sulfatos de Condroitina; Exossomos; Melanoma; Proteínas de Membrana; Neoplasias Cutâneas; Antígenos; Biomarcadores/análise; Líquidos Corporais; Proteoglicanas de Sulfatos de Condroitina/análise; Humanos; Melanoma/tratamento farmacológico; Melanoma/imunologia; Proteínas de Membrana/análise; Proteoglicanas; Neoplasias Cutâneas/tratamento farmacológico; Neoplasias Cutâneas/imunologia

Palavras-chave

Antigens; Extracellular vesicles; Immune system; Immunotherapy; Neoplasm

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoglicanas de Sulfatos de Condroitina / Neoplasias Cutâneas / Exossomos / Melanoma / Proteínas de Membrana Limite: Humans Idioma: En Revista: HNO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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