Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB.

Mohamady, Samy; Gibriel, Abdullah Ahmed; Ahmed, Mahmoud Salama; Hendy, Moataz S; Naguib, Bassem H

Mohamady, Samy; Gibriel, Abdullah Ahmed; Ahmed, Mahmoud Salama; Hendy, Moataz S; Naguib, Bassem H.

Afiliação

Mohamady S; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; Center of Drug Research and Development (CDRD), The British University in Egypt, Cairo, Egypt. Electronic address: samy.mohamady@bue.edu.eg.
Gibriel AA; Center of Drug Research and Development (CDRD), The British University in Egypt, Cairo, Egypt; Biochemistry & Molecular Biology Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Ahmed MS; Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: mahmoud.ahmed@utsouthwestern.edu.
Hendy MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; Center of Drug Research and Development (CDRD), The British University in Egypt, Cairo, Egypt.
Naguib BH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; Center of Drug Research and Development (CDRD), The British University in Egypt, Cairo, Egypt; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Bioorg Chem ; 96: 103641, 2020 03.

Article em En | MEDLINE | ID: mdl-32032844

Assuntos

Antineoplásicos/química; Antineoplásicos/farmacologia; Naftoquinonas/química; Naftoquinonas/farmacologia; Inibidores da Topoisomerase II/química; Inibidores da Topoisomerase II/farmacologia; Antineoplásicos/síntese química; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; DNA Topoisomerases Tipo II/metabolismo; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Células Hep G2; Humanos; Células MCF-7; Simulação de Acoplamento Molecular; Naftoquinonas/síntese química; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Relação Estrutura-Atividade; Tiadiazinas/síntese química; Tiadiazinas/química; Tiadiazinas/farmacologia; Inibidores da Topoisomerase II/síntese química

Palavras-chave

Cancer; HepG2; Hydrazino-triazolothiadiazine; MCF-7; Naphthoquinone; Topoisomerase II-B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Inibidores da Topoisomerase II / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

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