Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism.

Kristensen, Kristian K; Leth-Espensen, Katrine Zinck; Mertens, Haydyn D T; Birrane, Gabriel; Meiyappan, Muthuraman; Olivecrona, Gunilla; Jørgensen, Thomas J D; Young, Stephen G; Ploug, Michael

Kristensen, Kristian K; Leth-Espensen, Katrine Zinck; Mertens, Haydyn D T; Birrane, Gabriel; Meiyappan, Muthuraman; Olivecrona, Gunilla; Jørgensen, Thomas J D; Young, Stephen G; Ploug, Michael.

Afiliação

Kristensen KK; Finsen Laboratory, Rigshospitalet, DK-2200 Copenhagen N, Denmark.
Leth-Espensen KZ; Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Mertens HDT; Finsen Laboratory, Rigshospitalet, DK-2200 Copenhagen N, Denmark.
Birrane G; Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Meiyappan M; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5320 Odense M, Denmark.
Olivecrona G; BIOSAXS Group, European Molecular Biology Laboratory Hamburg, D-22607 Hamburg, Germany.
Jørgensen TJD; Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Young SG; Discovery Therapeutics, Takeda Pharmaceutical Company Ltd., Cambridge, MA 02142.
Ploug M; Department of Medical Biosciences, Umeå University, 901 87 Umeå, Sweden.

Proc Natl Acad Sci U S A ; 117(8): 4337-4346, 2020 02 25.

Article em En | MEDLINE | ID: mdl-32034094

Assuntos

Proteína 4 Semelhante a Angiopoietina/metabolismo; Lipase Lipoproteica/química; Triglicerídeos/sangue; Motivos de Aminoácidos; Proteína 4 Semelhante a Angiopoietina/genética; Animais; Anticorpos Monoclonais/metabolismo; Dimerização; Humanos; Hipertrigliceridemia/enzimologia; Hipertrigliceridemia/genética; Hipertrigliceridemia/metabolismo; Lipase Lipoproteica/genética; Lipase Lipoproteica/metabolismo; Desdobramento de Proteína; Receptores de Lipoproteínas/química; Receptores de Lipoproteínas/genética; Receptores de Lipoproteínas/metabolismo

Palavras-chave

GPIHBP1; HDX-MS; intravascular lipolysis; lipoprotein lipase; surface plasmon resonance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Proteína 4 Semelhante a Angiopoietina / Lipase Lipoproteica Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca

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