A positive feedback loop between Wnt/ß-catenin signaling and hTERT regulates the cancer stem cell-like traits in radioresistant nasopharyngeal carcinoma cells.

Chen, Kaihua; Chen, Li; Li, Ling; Qu, Song; Yu, Binbin; Sun, Yongchu; Wan, Fangzhu; Chen, Xishan; Liang, Renba; Zhu, Xiaodong

Chen, Kaihua; Chen, Li; Li, Ling; Qu, Song; Yu, Binbin; Sun, Yongchu; Wan, Fangzhu; Chen, Xishan; Liang, Renba; Zhu, Xiaodong.

Afiliação

Chen K; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Chen L; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Li L; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Qu S; Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, China.
Yu B; Guangxi Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Guangxi Medical University, Nanning, Guangxi, China.
Sun Y; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Wan F; Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, China.
Chen X; Guangxi Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, Guangxi Medical University, Nanning, Guangxi, China.
Liang R; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Zhu X; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

J Cell Biochem ; 121(11): 4612-4622, 2020 11.

Article em En | MEDLINE | ID: mdl-32065421

Assuntos

Regulação Neoplásica da Expressão Gênica/efeitos da radiação; Carcinoma Nasofaríngeo/patologia; Células-Tronco Neoplásicas/patologia; Tolerância a Radiação; Telomerase/metabolismo; Proteína Wnt1/metabolismo; beta Catenina/metabolismo; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Movimento Celular; Proliferação de Células; Retroalimentação Fisiológica; Humanos; Carcinoma Nasofaríngeo/genética; Carcinoma Nasofaríngeo/metabolismo; Carcinoma Nasofaríngeo/radioterapia; Neoplasias Nasofaríngeas/genética; Neoplasias Nasofaríngeas/metabolismo; Neoplasias Nasofaríngeas/patologia; Neoplasias Nasofaríngeas/radioterapia; Células-Tronco Neoplásicas/efeitos da radiação; Telomerase/genética; Células Tumorais Cultivadas; Proteína Wnt1/genética; beta Catenina/genética

Palavras-chave

Wnt/ß-catenin signaling; cancer stem cells; hTERT; nasopharyngeal carcinoma; radioresistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Células-Tronco Neoplásicas / Regulação Neoplásica da Expressão Gênica / Telomerase / Proteína Wnt1 / Beta Catenina / Carcinoma Nasofaríngeo Limite: Humans Idioma: En Revista: J Cell Biochem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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