Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder.

Sohn, Yoo-Kyoung; Son, Sumin; Choi, Yoonjoo; Hwang, Da-Eun; Seo, Hyo-Deok; Lee, Joong-Jae; Kim, Hak-Sung

Sohn, Yoo-Kyoung; Son, Sumin; Choi, Yoonjoo; Hwang, Da-Eun; Seo, Hyo-Deok; Lee, Joong-Jae; Kim, Hak-Sung.

Afiliação

Sohn YK; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Son S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Choi Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Hwang DE; Department of Statistics, Seoul National University, Seoul, Korea.
Seo HD; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Lee JJ; Yuhan Research Institute, Yuhan Corporation, Yongin, Korea.
Kim HS; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

Biotechnol Bioeng ; 117(6): 1904-1908, 2020 06.

Article em En | MEDLINE | ID: mdl-32068245

Assuntos

Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Complemento C3a/antagonistas & inibidores; Inflamação/tratamento farmacológico; Leucina/análogos & derivados; Leucina/farmacologia; Células Cultivadas; Ativação do Complemento/efeitos dos fármacos; Complemento C3a/imunologia; Humanos; Inflamação/imunologia; Modelos Moleculares

Palavras-chave

C3a; anaphylatoxin; inflammatory disease; protein binder; protein engineering; repebody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C3a / Inflamação / Leucina / Anti-Inflamatórios Limite: Humans Idioma: En Revista: Biotechnol Bioeng Ano de publicação: 2020 Tipo de documento: Article

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