Effects of Normobaric Hypoxia on Oxygen Saturation Variability.
High Alt Med Biol
; 21(1): 76-83, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-32069121
ABSTRACT
Background:
The study is the first to evaluate the effects of graded normobaric hypoxia on SpO2 variability in healthy individuals. Materials andMethods:
Twelve healthy males (mean [standard deviation] age 22 [4] years) were exposed to four simulated environments (fraction of inspired oxygen [FIO2] 0.12, 0.145, 0.17, and 0.21) for 45 minutes, in a balanced crossover design.Results:
Sample entropy, a tool that quantifies the irregularity of pulse oximetry fluctuations, was used as a measure of SpO2 variability. SpO2 entropy increased as the FIO2 decreased, and there was a strong significant negative correlation between mean SpO2 and its entropy during hypoxic exposure (r = -0.841 to -0.896, p < 0.001). In addition, SpO2 sample entropy, but not mean SpO2, was correlated (r = 0.630-0.760, p < 0.05) with dyspnea in FIO2 0.17, 0.145, and 0.12 and importantly, SpO2 sample entropy at FIO2 0.17 was correlated with dyspnea at FIO2 0.145 (r = 0.811, p < 0.01).Conclusions:
These findings suggest that SpO2 variability analysis may have the potential to be used in a clinical setting as a noninvasive measure to identify the negative sequelae of hypoxemia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximetria
/
Hipóxia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
High Alt Med Biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido