Targeting Age-Related Pathways in Heart Failure.
Circ Res
; 126(4): 533-551, 2020 02 14.
Article
em En
| MEDLINE
| ID: mdl-32078451
ABSTRACT
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Exercício Físico
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Transdução de Sinais
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Coração
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Insuficiência Cardíaca
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Miocárdio
Limite:
Aged
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Humans
Idioma:
En
Revista:
Circ Res
Ano de publicação:
2020
Tipo de documento:
Article