Crystal structure of the Menglà virus VP30 C-terminal domain.
Biochem Biophys Res Commun
; 525(2): 392-397, 2020 04 30.
Article
em En
| MEDLINE
| ID: mdl-32093889
ABSTRACT
The family Filoviridae contains many important human viruses, including Marburg virus (MARV) and Ebola virus (EBOV). Menglà virus (MLAV), a newly discovered filovirus, is considered a potential human pathogen. The VP30 C-terminal domain (CTD) of these filoviruses plays an essential role in virion assembly. In common with other filoviruses, MLAV VP30 CTD mainly exists as a dimer in solution. In this work, we determined the crystal structure of recombinant MLAV VP30 CTD monomer, verifying that C-terminal helix-7 (H7) is critical for the dimerization process. This study provides a preliminary model for investigation of MLAV VP30 CTD as an anti-filovirus drug development target.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Filoviridae
/
Infecções por Filoviridae
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2020
Tipo de documento:
Article