Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease.
Alzheimers Res Ther
; 12(1): 22, 2020 03 04.
Article
em En
| MEDLINE
| ID: mdl-32131891
ABSTRACT
BACKGROUND:
The Centiloid scale was developed to standardise the results of beta-amyloid (Aß) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer's disease neuropathologic change (ADNC) score of intermediate or high probability of Alzheimer's Disease (AD), final clinicopathological diagnosis of AD, and expert visual read of a positive Aß PET scan.METHODS:
Aß PET results in CL for 49 subjects were compared with post-mortem findings, visual read, and final clinicopathological diagnosis. The Youden Index was used to determine the optimal CL thresholds from receiver operator characteristic (ROC) curves.RESULTS:
A threshold of 20.1 CL (21.3 CL when corrected for time to death, AUC 0.97) yielded highest accuracy in detecting moderate or frequent plaque density while < 10 CL was optimal for excluding neuritic plaque. The threshold for ADNC intermediate or high likelihood AD was 49.4 CL (AUC 0.98). Those cases with a final clinicopathological diagnosis of AD yielded a median CL result of 87.7 (IQR ± 42.2) with 94% > 45 CL. Positive visual read agreed highly with results > 26 CL.CONCLUSIONS:
Centiloid values < 10 accurately reflected the absence of any neuritic plaque and > 20 CL indicated the presence of at least moderate plaque density, but approximately 50 CL or more best confirmed both neuropathological and clinicopathological diagnosis of Alzheimer's disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Peptídeos beta-Amiloides
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Tomografia por Emissão de Pósitrons
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Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Res Ther
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Austrália