Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan<sup>1</sup>.

Wu, Chi-Jung; Liu, Wei-Lun; Lai, Chih-Cheng; Chao, Chien-Ming; Ko, Wen-Chien; Wang, Hsuan-Chen; Dai, Ching-Tzu; Hsieh, Ming-I; Choi, Pui-Ching; Yang, Jia-Ling; Chen, Yee-Chun

Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan¹.

Wu, Chi-Jung; Liu, Wei-Lun; Lai, Chih-Cheng; Chao, Chien-Ming; Ko, Wen-Chien; Wang, Hsuan-Chen; Dai, Ching-Tzu; Hsieh, Ming-I; Choi, Pui-Ching; Yang, Jia-Ling; Chen, Yee-Chun.

Emerg Infect Dis ; 26(4): 804-806, 2020 04.

Article em En | MEDLINE | ID: mdl-32186508

ABSTRACT

ABSTRACT

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

Assuntos

Aspergillus fumigatus; Azóis; Antifúngicos/farmacologia; Antifúngicos/uso terapêutico; Aspergillus fumigatus/genética; Azóis/farmacologia; Farmacorresistência Fúngica; Proteínas Fúngicas/genética; Testes de Sensibilidade Microbiana; Taiwan/epidemiologia

Palavras-chave

Aspergillus fumigatus; HMG-CoA reductase; TR34/L98H; TR46/Y121F/T289A; Taiwan; antimicrobial resistance; azole resistance; azole use; cdr1B; clinical isolates; cyp51A; environments; fungi; humans

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Azóis Tipo de estudo: Clinical_trials / Risk_factors_studies País/Região como assunto: Asia Idioma: En Revista: Emerg Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article

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