Connecting cytokines and cellular signals in the nephron during CKD and hypertension.
Kidney Int
; 97(4): 651-653, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32200858
ABSTRACT
Chronic kidney disease features chronic inflammation and fibrosis, both of which contribute to and are exacerbated by arterial hypertension. The contribution of immune responses to renal sodium retention has received intense scrutiny. In this regard, the article by Furusho et al. details a mechanism wherein intrarenal TNFα augments salt-sensitive hypertension during CKD via activation of the WNK1-SPAKNCC phosphorylation cascade.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
/
Hipertensão
Limite:
Humans
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos