I2-Catalyzed transformation of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates.
Org Biomol Chem
; 18(14): 2678-2684, 2020 04 08.
Article
em En
| MEDLINE
| ID: mdl-32202293
ABSTRACT
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article