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Stability of mismatch negativity event-related potentials in a multisite study.
Roach, Brian J; Hamilton, Holly K; Bachman, Peter; Belger, Aysenil; Carrión, Ricardo E; Duncan, Erica; Johannesen, Jason; Kenney, Joshua G; Light, Gregory; Niznikiewicz, Margaret; Addington, Jean; Bearden, Carrie E; Owens, Emily M; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara A; McGlashan, Thomas H; Perkins, Diana O; Seidman, Larry; Tsuang, Ming; Walker, Elaine F; Woods, Scott W; Mathalon, Daniel H.
Afiliação
  • Roach BJ; Department of Psychiatry, San Francisco Veterans Affairs Healthcare System, San Francisco, California, USA.
  • Hamilton HK; Department of Psychiatry, San Francisco Veterans Affairs Healthcare System, San Francisco, California, USA.
  • Bachman P; Department of Psychiatry, University of California, San Francisco, California, USA.
  • Belger A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Carrión RE; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Duncan E; Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA.
  • Johannesen J; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
  • Kenney JG; Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York, USA.
  • Light G; Department of Psychiatry, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.
  • Niznikiewicz M; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Addington J; Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut, USA.
  • Bearden CE; Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut, USA.
  • Owens EM; Department of Psychiatry, University of California, San Diego, California, USA.
  • Cadenhead KS; Department of Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, California, USA.
  • Cannon TD; Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Cornblatt BA; Hotchkiss Brain Institute Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
  • McGlashan TH; Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California, Los Angeles, California, USA.
  • Perkins DO; Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California, Los Angeles, California, USA.
  • Seidman L; Department of Psychiatry, University of California, San Diego, California, USA.
  • Tsuang M; Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut, USA.
  • Walker EF; Department of Psychology, Yale University, School of Medicine, New Haven, Connecticut, USA.
  • Woods SW; Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA.
  • Mathalon DH; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
Int J Methods Psychiatr Res ; 29(2): e1819, 2020 06.
Article em En | MEDLINE | ID: mdl-32232944
OBJECTIVES: Mismatch negativity (MMN), an auditory event-related potential sensitive to deviance detection, is smaller in schizophrenia and psychosis risk. In a multisite study, a regression approach to account for effects of site and age (12-35 years) was evaluated alongside the one-year stability of MMN. METHODS: Stability of frequency, duration, and frequency + duration (double) deviant MMN was assessed in 167 healthy subjects, tested on two occasions, separated by 52 weeks, at one of eight sites. Linear regression models predicting MMN with age and site were validated and used to derive standardized MMN z-scores. Variance components estimated for MMN amplitude and latency measures were used to calculate Generalizability (G) coefficients within each site to assess MMN stability. Trait-like aspects of MMN were captured by averaging across occasions and correlated with subject traits. RESULTS: Age and site accounted for less than 7% of MMN variance. G-coefficients calculated at electrode Fz were stable (G = 0.63) across deviants and sites for amplitude measured in a fixed window, but not for latency (G = 0.37). Frequency deviant MMN z-scores averaged across tests negatively correlated with averaged global assessment of functioning. CONCLUSION: MMN amplitude is stable and can be standardized to facilitate longitudinal multisite studies of patients and clinical features.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudos Multicêntricos como Assunto / Eletroencefalografia / Potenciais Evocados Auditivos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Int J Methods Psychiatr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudos Multicêntricos como Assunto / Eletroencefalografia / Potenciais Evocados Auditivos Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Int J Methods Psychiatr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos